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Active immunisation against hepatitis B
Adult: Primary immunisation: As recombinant HBsAg vaccine 18-19 years 10 mcg/0.5 mL for 3 doses given at 0, 1, and 6 months; ≥20 years 20 mcg/mL for 3 doses given at 0, 1, and 6 months. An accelerated immunisation schedule given at 0, 1, 2, and 12 months may be followed. As recombinant, adjuvanted HBsAg vaccine: 20 mcg/0.5 mL for 2 doses given at least 1 month apart. Dosage and vaccination schedule recommendations may vary according to individual products and between countries (refer to specific product or official country guidelines).
Child: Primary immunisation: As recombinant HBsAg vaccine: Infants Born to HBsAg-negative mothers: 10 mcg/0.5 mL given within 24 hours of birth for the 1st dose, then given at 1-2 months of age for the 2nd dose, and at 6-18 months of age for 3rd dose; if birthweight is <2 kg, give the initial dose at 30 days of chronological age or at hospital discharge (whichever is 1st). Born to HBsAg-positive mothers: 1st dose: 10 mcg/0.5 mL given within the 1st 12 hours of life (regardless of birth weight) and administered simultaneously with hepatitis B immunoglobulin at a separate inj site; 2nd dose: Birthweight <2 kg: 10 mcg/0.5 mL given at 1 month of age; ≥2 kg: 10 mcg/0.5 mL given at 1-2 months of age; 3rd dose: Birthweight <2 kg: 10 mcg/0.5 mL given at 2-3 months of age; ≥2 kg: 10 mcg/0.5 mL given at 6 months of age; 4th dose: Birthweight <2 kg: 10 mcg/0.5 mL given at least 6 months of age (24 weeks). Born to mothers with unknown HBsAg status: Follow the vaccination schedule of those born to HBsAg-positive mothers, then once maternal status is determined follow the applicable vaccination schedule. ≤17 years 10 mcg/0.5 mL for 3 doses given at 0, 1, and 6 months. An accelerated immunisation schedule given at 0, 1, 2, and 12 months may be followed. Dosage and vaccination schedule recommendations may vary according to individual products and between countries (refer to specific product or official country guidelines).
Neonate: Primary immunisation: As recombinant HBsAg vaccine: Born to HBsAg-negative mothers: Birthweight <2 kg: 10 mcg/0.5 mL given at 30 days of chronological age or at hospital discharge (whichever is 1st); ≥2 kg: 10 mcg/0.5 mL given within 24 hours of birth for the 1st dose. Born to HBsAg-positive mothers: 1st dose: 10 mcg/0.5 mL given within the 1st 12 hours of life (regardless of birth weight) and administered simultaneously with hepatitis B immunoglobulin at a separate inj site; 2nd dose: Birthweight <2 kg: 10 mcg/0.5 mL given at 1 month of age; ≥2 kg: 10 mcg/0.5 mL given at 1-2 months of age; 3rd dose: Birthweight <2 kg: 10 mcg/0.5 mL given at 2-3 months of age; ≥2 kg: 10 mcg/0.5 mL given at 6 months of age; 4th dose: Birthweight <2 kg: 10 mcg/0.5 mL given at least 6 months of age (24 weeks). Born to mothers with unknown HBsAg status: Follow the vaccination schedule of those born to HBsAg-positive mothers, then once maternal status is determined follow the applicable vaccination schedule. Dosage and vaccination schedule recommendations may vary according to individual products and between countries (refer to specific product or official country guidelines).
Child: Primary immunisation: As recombinant HBsAg vaccine: Infants Born to HBsAg-negative mothers: 10 mcg/0.5 mL given within 24 hours of birth for the 1st dose, then given at 1-2 months of age for the 2nd dose, and at 6-18 months of age for 3rd dose; if birthweight is <2 kg, give the initial dose at 30 days of chronological age or at hospital discharge (whichever is 1st). Born to HBsAg-positive mothers: 1st dose: 10 mcg/0.5 mL given within the 1st 12 hours of life (regardless of birth weight) and administered simultaneously with hepatitis B immunoglobulin at a separate inj site; 2nd dose: Birthweight <2 kg: 10 mcg/0.5 mL given at 1 month of age; ≥2 kg: 10 mcg/0.5 mL given at 1-2 months of age; 3rd dose: Birthweight <2 kg: 10 mcg/0.5 mL given at 2-3 months of age; ≥2 kg: 10 mcg/0.5 mL given at 6 months of age; 4th dose: Birthweight <2 kg: 10 mcg/0.5 mL given at least 6 months of age (24 weeks). Born to mothers with unknown HBsAg status: Follow the vaccination schedule of those born to HBsAg-positive mothers, then once maternal status is determined follow the applicable vaccination schedule. ≤17 years 10 mcg/0.5 mL for 3 doses given at 0, 1, and 6 months. An accelerated immunisation schedule given at 0, 1, 2, and 12 months may be followed. Dosage and vaccination schedule recommendations may vary according to individual products and between countries (refer to specific product or official country guidelines).
Neonate: Primary immunisation: As recombinant HBsAg vaccine: Born to HBsAg-negative mothers: Birthweight <2 kg: 10 mcg/0.5 mL given at 30 days of chronological age or at hospital discharge (whichever is 1st); ≥2 kg: 10 mcg/0.5 mL given within 24 hours of birth for the 1st dose. Born to HBsAg-positive mothers: 1st dose: 10 mcg/0.5 mL given within the 1st 12 hours of life (regardless of birth weight) and administered simultaneously with hepatitis B immunoglobulin at a separate inj site; 2nd dose: Birthweight <2 kg: 10 mcg/0.5 mL given at 1 month of age; ≥2 kg: 10 mcg/0.5 mL given at 1-2 months of age; 3rd dose: Birthweight <2 kg: 10 mcg/0.5 mL given at 2-3 months of age; ≥2 kg: 10 mcg/0.5 mL given at 6 months of age; 4th dose: Birthweight <2 kg: 10 mcg/0.5 mL given at least 6 months of age (24 weeks). Born to mothers with unknown HBsAg status: Follow the vaccination schedule of those born to HBsAg-positive mothers, then once maternal status is determined follow the applicable vaccination schedule. Dosage and vaccination schedule recommendations may vary according to individual products and between countries (refer to specific product or official country guidelines).
